By TOM MURPHY, Associated Press Health Writer

Shares of some big drugmakers jumped ahead of broader indexes Friday as Wall Street started sorting out President Donald Trump’s latest tariff announcement.

The president said late Thursday that he would place 100% import taxes on pharmaceuticals starting Oct. 1, but those tariffs would not apply to companies building U.S. manufacturing plants. He defined that as either “breaking ground” or being “under construction.”

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Several big drugmakers like Merck & Co. Inc., Eli Lilly and Co. and Johnson & Johnson have announced U.S. expansion plans.

Trump has talked about pharmaceutical tariffs for months, but he has said he would delay them for a year or a year and a half to give companies time to stockpile medicines here and shift manufacturing.

Analysts have said companies started stockpiling medicines in the U.S. earlier this year.

Jefferies analyst Akash Tewari said in a research note that Thursday’s announcement shouldn’t have a material impact on the big drugmakers, given their construction plans.

Brand-name drug companies also have fat profit margins that can provide some flexibility to make investments and absorb tariff costs. Manufacturers of cheaper generic drugs — which account for most U.S. prescriptions — do not. Researchers and patient advocates have worried about the impact of any tariffs on those companies.

David Risinger of Leerink Partners said smaller drugmakers also may be vulnerable to the new taxes, although he noted that it was hard to predict which ones.

He said several questions remain unanswered after Thursday’s announcement. Those include whether the action will survive legal challenges and how the phrases “breaking ground” and “under construction” are defined for tariff enforcement.

Risinger also questioned whether the new taxes might be a negotiating tactic tied to an investigation the administration launched in the spring over how importing drugs and their ingredients affects national security.

Shares of Merck and Lilly both climbed more than 1% Friday morning, while J&J’s stock rose slightly. The S&P 500 also edged slightly higher.

Minnesota United vs. Colorado Rapids

When: 8:30 p.m. (CT) Saturday
Where: Dick’s Sporting Goods Park
Stream: MLS Season Pass on Apple TV
Radio: KSTP-AM, 1500
Weather: 73 degrees, clear skies, 10 mph north wind
Betting line: MNUFC plus-125; draw plus-270; Colorado plus-125

Form: Third-place MNUFC (15-7-9, 54 points) have dropped two straight, including a 3-0 loss to Chicago last Saturday. Eighth-place Colorado (11-14-6, 39 points) has lost three of four, including a 3-1 defeat to FC Dallas last weekend.

Recent matchups: MNUFC suffered one of its biggest home letdowns of the season to the Rapids, a 2-1 loss on Aug. 10. After trading Djordje Mahailovic days earlier, Darren Yapi scored both goals for the road side.

Context: With only three regular-season matches left, Minnesota’s priority is to hold onto a top four spot in the Western Conference. With that comes home-field advantage in the best-of-three, first-round series.

Check-in: Former Loons forward Tani Oluwaseyi registered his first goal and first assist for Villarreal in Spain’s La Liga over the last week. His debut goal came on a decisive run into the box and tap-in finish against Sevilla on Tuesday.

Absences: CB Nico Romero (yellow-card suspension), FW Kelvin Yeboah (hamstring) and CB/MF Carlos Harvey (knee) are out.

Context: New forward Momo Dieng led MNUFC with 0.7 expected goals against Chicago, but none of his three shots were on frame. New attacking midfielder Dominik Fitz had a team-high 0.5 expected assists, per FBRef.com. That’s something to build on.

Projected starting lineup: FW Momo Dieng; AM Dominik Fitz, AM Robin Lod, CM Wil Trapp, CM Nector Triantis; LWB Anthony Markanich, CB Jefferson Diaz, CB Michael Boxall, CB Morris Duggan, RWB Bongi Hlongwane; GK Dayne St. Clair.

Scouting report: Colorado has conceded 11 goals across its last four (2.75 per match), but Minnesota has scored only five in its last four in all competitions (1.25 per match). The Rapids’ defense might be an elixir to what ails Minnesota in the post-Oluwaseyi era.

Stat: The Loons lead MLS with $4.9 million in General Allocation Money to spend on its roster. San Diego is second at $3.4 million and they were issued an additional $2.7 million as an expansion club. This money no longer expires.

Prediction: MNUFC is coming off its worst week of the season — primarily in the 2-1 loss to Austin in the U.S. Open Cup semifinal — and had a full week after the Chicago loss to forget about it. They will have a tough time — at altitude — proving they are still a top team in the West, but they get it done with a 2-1 win.

Colorado’s mountain towns are destinations for hiking, biking, hot springs and more, but choose the right one and you’ll also tap into music scenes that are destinations in their own right.

Here are five places worth adding to any music fan’s bucket list. Don’t forget to pack your dancing shoes.

Aspen

Aspen is a small town with big city energy when it comes to live music, thanks to its mix of venues, festivals and sporting events that draw bands from around the country. Belly Up Aspen is the premiere club to catch a concert whether you’re a fan of EDM, country music, blues, indie rock or reggae. The historic Wheeler Opera House caters to fans of classical music and opera. And the festival season runs year-round with winter attractions like Palm Tree Music Festival and summer events like Up in the Sky Festival. In June, the Jazz Aspen Snowmass festival takes over the town with a plethora of events at indoor and outdoor venues, before its sister festival, JAS Labor Day Experience, pops up with a more traditional main stage festival experience in the fall. All that, plus free shows during ski season and summer make Aspen a must-visit for music lovers.

Buena Vista

Whether you’re a casual music fan or a hardcore festivarian, Buena Vista has the tunes to sonically satisfy. The town’s most high-profile venue is Meadow Creek, a sprawling 277-acre plot of land used as a festival grounds complete with the full destination camping experience. Previously the site of Billy Strings’ Renewal festival, in 2025, Meadow Creek hosts Pretty Lights for the two-day Yahn Dawn festival (June 27-28) and King Gizzard and the Lizard Wizard for a three-day event called Field of Vision (Aug. 15-17).

Downtown Buena Vista boasts several indoor venues, such as the Ivy Ballroom at the Surf Hotel and The Lariat, that host local and nationally touring bands across a variety of genres. When the weather is nice, fans can take in a concert at outdoor spaces like The Lawn (also at the Surf Hotel) and The Beach, located 6 miles south of town on the banks of the Arkansas River.

Dillon

First opened in the 1990s, the Dillon Amphitheater got a major upgrade in 2018 and has become the hallmark of the town’s summer music scene. It regularly attracts artists you might otherwise see on the lineup at Red Rocks Amphitheatre, including Alison Krauss & Union Station, Tash Sultana and Rainbow Kitten Surprise in the 2025 season. But with a roughly 3,600-person capacity – less than half that of Red Rocks – seeing those acts in Dillon promises to be a more intimate experience. And because it’s located on the shore of Lake Dillion, which is surrounded by peaks, the view isn’t bad either. Shows usually require a ticket, but not always, as bands play for free as part of the venue’s Monday music series.

Telluride

Telluride Bluegrass “festivarians” race to get a close spot to the stage during the annual “running of the tarps” on the first day of the 50th Telluride Bluegrass Festival in Town Park in Telluride, Colorado, on June 15, 2023. (Photo by William Woody/Special to The Denver Post)

Though it’s one of Colorado’s far-out enclaves, Telluride is a stop on nationally touring bands’ calendars because of the myriad festivals it hosts each summer. The box canyon comes alive with the sound of music for events like the Telluride Bluegrass Festival in June, which has become a time-honored tradition for locals and artists alike over its 50-plus year history, and Telluride Jazz Festival in August, which includes a second line parade down Colorado Avenue every year. Free concerts on Wednesdays and Fridays in Mountain Village, which is just a short gondola ride away, keep the vibes rolling through the summer before the season concludes with the incomparable Telluride Blues & Brews Festival in September.

Even in the winter, though, fans are likely to catch an act they like at the historic Sheridan Opera House or local bars like The Alibi and O’Bannon’s Irish Pub. The ski resort also books local DJs to play at restaurants on the mountain, because dancing is the best way to stay warm – trust us.

Vail

Similarly to Dillon, the town of Vail boasts a state-of-the-art amphitheater that bands forgo radius clauses to perform at. The Gerald R. Ford Amphitheater opened in 1987, and in July of that year, Willie Nelson was the first artist to christen the stage. The outdoor venue has grown from hosting six concerts in its first year to dozens, including acclaimed acts like O.A.R. and Melissa Etheridge, both of whom will be stopping by this summer after performances at Red Rocks. The amphitheater is also known for hosting dance performances and classical music, like the annual Bravo! Vail Music Festival.

Elsewhere in Vail, Shakedown Bar is a mainstay for live music with performers almost every night of the week, and Chasing Rabbits is the place to dance the night away to the tune of DJs. All the aforementioned venues book their calendars in the winter months, too, from après hour to late night.

Like a virus, desperation thrives in the unforgiving cold of Northern Minnesota in “Dead of Winter.”

The environment heightens the largely engrossing kidnapping thriller, which is in theaters this week.

Its principal characters are desperate — mostly desperate to survive. However, the primary figure, Emma Thompson’s Barb, is desperate to save the life of another.

Barb has returned to this largely uninhabited area to visit a lake that played a key role in the life she shared with her late husband.

“Ya HAD to pick the middle of nowhere,” she grumbles to herself before venturing outside for a task that later will become clear.

On the frozen-over body of water, as she’s about to accomplish what she came to do — Thompson reminding the viewer of her talents as a long tear eventually cascades down Barb’s face — she hears gunshots and voices. She hides behind her truck as a young woman is chased by a man who insists his next shot won’t miss if she does not return to him.

Barb had encountered this man, referred to as Camo Jacket (Marc Menchaca), at his cabin while seeking directions to the lake amid the wintry conditions, so she soon ventures back there in the hope of discovering what foul business is afoot. Looking through a window, she sees the young woman, Leah (Laurel Marsden), restrained in the basement.

Arriving next is Purple Lady (Judy Greer), the short-tempered wife of Camo Jacket. She confirms with him that the abduction of Leah went as planned — he assures her that, yes, the girl was where his wife said she’d be — and scolds him for drinking during this all-important endeavor.

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What Purple Lady wants from Leah becomes clear over time. First, though, Purple Lady becomes aware of Barb’s involvement, setting into motion what becomes a shifting game of cat and mouse. Purple Lady and Barb try to outsmart each other, the action shifting between the cabin and the lake.

Working from a screenplay by Nicholas Jacobson-Larson and Dalton Leeb, Irish filmmaker Brian Kirk serves up a taut affair, one with enough, but not too much, tension. “Dead of Winter” makes you hold your breath occasionally but largely lets you take in that brutally cold air.

It makes you want to see more big-screen work from Kirk, whose credits include 2019’s “21 Bridges” and myriad TV series episodes, including three first-season installments of “Game of Thrones” and, more recently, three servings of the solid British series “The Day of the Jackal,” available in these parts on Peacock.

The film’s largest flaw is that Jacobson-Larson, Leeb and Kirk make next to no effort to develop Leah into a character. She feels too important to the story to be nothing more than Purple Lady’s prize. Furthermore, the kidnapper does make a claim about Leah that seems ripe for exploration, but we don’t get that.

Conversely, the character of Barb is nicely fleshed out, with renowned actress Thompson (“Howard’s End,” “Sense and Sensibility,” “Nanny McPhee”), as you’d expect, nuanced in her portrayal of this determined woman who tiptoes into the realm of the unlikely action hero. (In flashbacks that inform the character, Barb is portrayed as a young woman by Thompson’s daughter, Gaia Wise, and the resemblance is unmistakable.)

While movie and TV veteran Greer (“The Best Christmas Pageant Ever,” “Stick”) is solid, Menchaca (“The Outsider,” “Ozark”) turns in the other standout performance. Without giving away too much, Camo Jacket doesn’t exactly have the time of his life as the events of “Dead of Winter” unfold, and Menchaca conveys his struggle skillfully.

(A quick digression: Did the writers and directors think of the movie reviewers who would have to write “Purple Lady” and “Camo Jacket” repeatedly? They couldn’t have just been, say, Jennifer and Steve?)

A few gripes aside, “Dead of Winter” is a well-executed enterprise. It’s modest in ambitious, sure, but Kirk and Co. likely had a relatively small budget, and, if that’s a correct assumption, they’ve made the most of it.

Unfortunately, as summer has just given way to fall, it’s a harsh reminder that, for many of us, a cold winter is coming.

‘Dead of Winter’

Where: Theaters.

When: Sept. 26.

Rated: R for violence and language.

Runtime: 1 hour, 37 minutes.

Stars (of four): 2.5.