The Twins had runners on the corners and one out in the first inning. They came away with nothing. An inning later, they had the bases loaded with just one out. They scored just one run.

The Twins were unable to take full advantage of their early chances and simply had no chances late, quieted by starter Andre Pallante, who threw seven innings, in a 6-1 loss to the St. Louis Cardinals in the series opener Friday night at Target Field.

Stretching from the third inning to the bottom of the ninth, Cardinals (64-64) pitchers retired 16 straight Twins (71-57) batters, most of whom grounded out in a slow night for the offense. Matt Wallner became the first baserunner since the early innings when he drew a walk to lead off the last frame.

“We needed to have many more good at-bats today than we had,” manager Rocco Baldelli said. “It was hard early on because we had bases loaded, we had first and third, we had opportunities to do some things. There’s so many different ways for us to score when we’re in those spots. We just couldn’t find it today.”

Cardinals hitters had no such problems.

Rookie David Festa was unhittable during his first turn through the lineup, striking out four. But the second time through, he gave up three hits and was eventually chased from the game.

Festa lasted just 3 2/3 innings, allowing a run in the top of the third inning to tie the game and another pair of runs on a Lars Nootbaar double in the fourth inning that gave St. Louis the lead for good.

“I thought they just did a great job of working at-bats,” Festa said. “I didn’t get a lot of first pitch, second-pitch outs. … I don’t think it had anything to do with the second time around more than just battling and putting together really good at-bats.”

The short start pressed bullpen that has had a tough go of it lately into action early.

The Twins got 1 1/3 scoreless innings from Caleb Thielbar before Jorge Alcala, pitching in his first game since allowing five runs to Texas last weekend, gave up a leadoff home run to Brendan Donovan in the sixth inning and then slogged through the rest of the inning, issuing a pair of walks.

Trevor Richards, in his second inning of work, gave up another pair of runs as the Cardinals pulled away in the eighth inning. One of those runs scored on a bases-loaded walk. In total, Twins pitchers issued nine walks.

The Twins’ lone run in the loss, which dropped them behind the Kansas City Royals to third place in the American League Central division, came in the second inning when Austin Martin beat out an infield single with the bases loaded, bringing home catcher Ryan Jeffers for a lead they held just briefly.

“It became kind of a … battle for our bullpen to just keep us where we’re at,” Baldelli said. “We did it for a little while but ultimately we couldn’t make up the deficit.”

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Pablo López is excited to pitch against his former teammate Sonny Gray on Saturday night, sure. But what he really wants to do, well, he won’t have the chance.

“I wish I was hitting against him,” López lamented.

The duo faced off against each other twice in 2019 while they both pitched for National League teams, and both pitchers are hitless against each other. But they’ll have to fill their competitive itch against each other on the mound only now, and it’s a matchup that both pitchers, who fronted the Twins’ rotation last season together, are looking forward to.

López and Gray, who signed a three-year deal with the St. Louis Cardinals after pitching for the Twins for two seasons, will face off Saturday in a game beginning at 6:10 p.m. at Target Field.

“I got to learn from him, and now going up against him is going to be fun to just have that extra competitive edge going against Sonny, who we all know is a tough competitor, one of the toughest guys out there,” López said. “It’s going to be a really fun challenge to go head-to-head against him.”

Gray, who has a 3.91 earned-run average currently in his first season in St. Louis, is anticipating it as well.

“I have nothing but the most respect for Pablo. I thoroughly, thoroughly, throughly enjoyed working with him last year,” Gray said. “We both brought so much out of each other, I would say. Having another guy like him on the staff that was as dominant, it made me better. I’d like to hope that I was able to help him and make him better. But he definitely made me better.”

Gray’s impact is still felt within the Twins’ clubhouse, where he mentored younger members of the rotation, like Joe Ryan and Bailey Ober, both of whom praised him as a leader.

Twins manager Rocco Baldelli said Gray, now 34, showed younger pitchers that there is a level and a trait of determination and focus necessary to succeed that he thinks brushed off on younger pitchers.

And while Gray said he was told upfront by the front office early in free agency that they did not have the resources to re-sign him, he looks back on his time with Minnesota fondly.

“This was a really good place for me and my family for two years,” Gray said. “We loved our time here.”

Buxton progressing

Byron Buxton was initially hoping to avoid the injured list entirely. Then, he was hoping to be back after 10 days, on the first day he was eligible.

Neither happened, but the Twins’ center fielder, who is dealing with hip inflammation, has accepted that that’s best both for him and for the team.

“(I was) not rushing it but just trying to get back at 10 days,” Buxton said. “One of those things that just didn’t work out. Just staying positive. Understanding if things didn’t work out in 10 days, it’ll be better at some point.”

Buxton said he has been feeling better, though he said he’s still feeling the inflammation when he runs. His swing feels fine and defense and throwing both feel good. So now, it’s just getting over the hurdles of running, even if he isn’t 100 percent.

“It’s that point in the season where you aren’t going to be perfect,” he said. “So it’s just more about the toleration of what I can take.”

Buxton said he hopes to avoid going on a rehab assignment. Earlier in the week, head athletic trainer Nick Paparesta said the decision on whether he needs to play in rehab games would be at “a player’s discretion at this stage.”

At this point, with the Twins currently in possession of a wild card berth and in the hunt for the American League Central Division title, Buxton understands the importance of every game — which is he why he understands why missing some now might be better overall in the long run.

“One of those things where, don’t try to do anything crazy,” Buxton said. “We are where we are in the season and there’s no place I’d rather be than to be playing. But it’s also that point in not trying to go out there too quick and have another setback.”

Briefly

Alex Kirilloff (back) started a rehab assignment on Friday with Triple-A St. Paul, and Brooks Lee (biceps) will play on Saturday in St. Paul, Baldelli said. “They’ll both be in the lineup on the 25th, and then they can go from there. They’ll keep playing. They’re not going to be immediately activated at that point.”

The only thing head coach Kevin O’Connell was willing to confirm this week heading into the preseason finale between the Vikings and Eagles is that Jaren Hall will start at quarterback in Philadelphia, then Matt Corral will eventually take over down the stretch.

In other words, Sam Darnold and Nick Mullens will not be playing, which makes sense given the fact that they’re the only healthy quarterbacks on the roster.

It’s safe to assume there will be a good amount of players joining Darnold and Mullens on the sidelines. There’s no sense in playing any of the established players at this point. Not with so many position battles still hanging in the balance with less than a week before the initial 53-man roster is due.

“We have a lot of things we’ll have to let work itself out via competition,” O’Connell said. “The game will still be a part of the evaluation process.”

Here are five storylines to watch in the Vikings preseason finale:

How does Jaren Hall look?

This is the last chance for Hall to make a statement that he belongs.

Though he fills an important role behind Darnold and Mullens, especially with J.J. McCarthy on injured reserve, Hall is likely on the fringe of making the team with the way things are shaping up elsewhere on the roster.

As the Vikings decide between which players to hold on to, and which players to move on from, there’s a chance they cut Hall with hopes of sneaking him onto the practice squad. The risk there is Hall could be claimed off waivers by another team.

How are things going to play out? That remains to be seen. If Hall puts together a solid effort, however, he might make himself too valuable to expose.

Which receivers sit out?

Aside from Justin Jefferson and Jordan Addison, the Vikings could decide that every receiver has to suit up. That has been the case so far throughout the exhibition slate.

That said, if somebody like Jalen Nailor, or even somebody like Trishton Jackson, is in street clothes on the sidelines, it would serve as a pretty good indicator that they have made the team. The same goes for Brandon Powell and Trent Sherfield.

Never mind that it seems antithetical to being in the NFL. Not playing in the preseason finale is a good thing.

Which cornerbacks step up?

Not counting Stephon Gilmore, Shaq Griffin and Byron Murphy Jr., there are maybe a couple of spots up for grabs among the other cornerbacks in the room.

Te biggest riser over the past couple of weeks has been Dwight McGlothern. The undrafted free agent has made a number of plays throughout training camp, to go along with an interception that he nearly returned for a touchdown last weekend against Cleveland.

If the Vikings want to keep McGlothern, they might have to move on from somebody like Fabian Moreau or Akayleb Evans to do it. There are also a number of depth players that will presumably be competing for a couple of spots on the practice squad.

Those decisions could come down to who plays better in the preseason finale.

Is this it for Lewis Cine?

The ship might’ve already sailed on Cine despite his impressive performance last weekend against Cleveland. He finished with 10 tackles, a sack and an interception while playing every snap on defense.

Were the Vikings simply trying to showcase Cine with hopes that another team would trade for him? Perhaps.

That said, if Cine has a similar type of impact in the preseason finale, the Vikings could decide to hold on to him.

What does Kevin O’Connell say?

It was announced this week that the Vikings will have O’Connell mic’d up during Saturday’s game.

This is a fun thing the Vikings have been doing throughout the exhibition slate with Jefferson and Harrison Smith also partaking at different points.

Though he’s unlikely to give away any trade secrets, it will be interesting to hear from O’Connell with live action going on in front of him.

Minnesota Vikings safety Lewis Cine (6) celebrates his sack against the Cleveland Browns during the second half of an NFL preseason football game, Saturday, Aug. 17, 2024, in Cleveland. (AP Photo/Sue Ogrocki)

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