What to know about mRNA vaccines

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By LAURAN NEERGAARD, AP Medical Writer

WASHINGTON (AP) — So-called mRNA vaccines saved millions of lives during the COVID-19 pandemic — and now scientists are using that Nobel Prize-winning technology to try to develop vaccines and treatments against a long list of diseases including cancer and cystic fibrosis.

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But this week, U.S. Health Secretary Robert F. Kennedy Jr., a longtime vaccine critic, canceled $500 million in government-funded research projects to create new mRNA vaccines against respiratory illnesses that might trigger another health emergency.

That dismays infectious disease experts who note that mRNA allows faster production of shots than older vaccine-production methods, buying precious time if another pandemic were to emerge.

Using older technology to target a pandemic flu strain would take 18 months to “make enough vaccine to vaccinate only about one-fourth of the world,” said Michael Osterholm of the University of Minnesota, an expert on pandemic preparation. But using mRNA technology “could change that dramatically, such that by the end of the first year, we could vaccinate the world.”

How mRNA technology works

Traditionally, making vaccines required growing viruses or pieces of viruses called proteins — often in giant vats of cells or, like most flu shots, in chicken eggs — and then purifying them. Injecting a small dose as a vaccine trains the body how to recognize when a real infection hits so it’s ready to fight back.

But that technology takes a long time. Using mRNA is a faster process.

The “m” stands for messenger, meaning mRNA carries instructions for our bodies to make proteins. Scientists figured out how to harness that natural process by making mRNA in a lab.

They take a snippet of that genetic code that carries instructions for making the protein they want the vaccine to target. Injecting that snippet instructs the body to become its own mini-vaccine factory, making enough copies of the protein for the immune system to recognize and react.

The COVID-19 vaccines aren’t perfect

Years of research show protection from COVID-19 vaccines — both the types made with mRNA and a type made with traditional technology — does wane over time. The vaccinations provide the strongest protection against severe infection and death, even if people still become infected.

But that’s a common feature with both the coronavirus and flu because both viruses continually mutate. That’s the reason we’re told to get a flu vaccine every year — using vaccines made with traditional methods, not mRNA.

Today’s COVID-19 vaccines made with mRNA by Pfizer and Moderna can be updated more quickly each year than traditional types, an advantage that now has multiple companies developing other vaccines using the technology.

Traditional vaccines aren’t the only use for mRNA

Osterholm counts about 15 infectious disease vaccines that could benefit from mRNA technology, but that’s not the only potential. Many disease therapies take aim at proteins, making mRNA a potential technique for developing new treatments. Researchers already are testing an mRNA-based therapeutic vaccine for pancreatic cancer. Genetic diseases are another target, such as an experimental inhaled therapy for cystic fibrosis.

AP video journalist Nathan Ellgren contributed to this report.

The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education and the Robert Wood Johnson Foundation. The AP is solely responsible for all content.

Tribal groups assert sovereignty as feds crack down on gender-affirming care

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By Jazmin Orozco Rodriguez, KFF Health News

ELKO, Nev. — At the Two Spirit Conference in northern Nevada in June, Native Americans gathered in support of the LGBTQ+ community amid federal and state rollbacks of transgender protections and gender-affirming health care.

“I want people to not kill themselves for who they are,” said organizer Myk Mendez, a trans and two-spirit citizen of the Fort Hall Shoshone-Bannock Tribes in Idaho. “I want people to love their lives and grow old to tell their stories.”

“Two-spirit” is used by Native Americans to describe a distinct gender outside of male or female.

The conference in Elko reflects how some tribal citizens are supporting their LGTBQ+ community members as President Donald Trump rolls back protections and policies. In March, the National Indian Health Board, which represents and advocates for federally recognized Native American and Alaska Native tribes, passed a resolution declaring tribal sovereignty over issues affecting the Native American community’s health, including access to gender-affirming care.

The resolution calls on the federal government to preserve and expand programs that support the health and well-being of two-spirit and LGBTQ+ Native Americans. Tribes and tribal organizations are navigating how to uphold their sovereignty without jeopardizing the relationships and resources that support their communities, said Jessica Leston, the owner of the Raven Collective, a Native public health consulting group, and a member of the Ketchikan Indian Community.

In January, Trump signed an executive order recognizing only two sexes — male and female — and another to terminate diversity, equity, and inclusion programs within the federal government.

An Indian Health Service website describing two-spirit people was removed this year but restored following a court order. The page now has a disclaimer at the top that declares any information on it “promoting gender ideology” is “disconnected from the immutable biological reality that there are two sexes, male and female.”

Two-spirit is not a sexual orientation but refers to people of a “culturally and spiritually distinct gender exclusively recognized by Native American Nations,” according to a definition created by two-spirit elders in 2021. According to two-spirit leaders, people who did not fit into the Western binary of male and female have lived in their communities since before colonization.

Already, tribal citizens and leaders say some people have had trouble accessing gender-affirming care in recent months, with some community members being denied hormone treatments or having their medications delayed, even in places where gender-affirming care remains legal. Panic has spread, and tribal citizens have considered leaving the country.

“There is a chilling effect,” said Itai Jeffries, who is trans, nonbinary, and two-spirit, of the Occaneechi people from North Carolina, and a consultant for the Raven Collective.

Mendez said he requested hormone treatment at his local Indian Health Service clinic at the end of June and was told by his provider that the facility has had trouble receiving the treatment for patients.

Lenny Hayes, a two-spirit citizen of the Sisseton-Wahpeton Oyate in South Dakota, said the Indian Health Service clinic on the reservation also isn’t dispensing hormone treatment, though it is legal for people 18 and older. Hayes is the owner and operator of Tate Topa Consulting and provides educational training on two-spirit and LGTBQ+ Native Americans and Alaska Natives.

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The National Congress of American Indians passed a resolution in 2015 to encourage the creation of policies to protect two-spirit and LGBTQ+ communities. And the organization adopted a resolution in 2021 to support providing gender-affirming care in Indian Health Service, tribal, and urban facilities.

The National Indian Health Board’s resolution cites homophobia and transphobia as contributing to higher rates of truancy, incarceration, self-harm, attempted suicide, and suicide among two-spirit young people. The board also lists health disparities among the broader Native LGBTQ+ population, including increased risks of anxiety, depression, and suicide.

Two-spirit and LGBTQ+ Native American and Alaska Native young people are particularly vulnerable to depression, suicidality, and sexual exploitation. In Minnesota, a 2019 state survey found that two-spirit and LGBTQ+ Native American and Alaska Native students had the highest rates of those ages 15-19 who responded “yes” to having traded sex or sexual activity for money, food, drugs, alcohol, or shelter.

Tribal leaders are also concerned that Medicaid cuts recently approved in Trump’s budget law will undercut efforts to expand testing and treatment for HIV infection in Native American communities.

The rates of HIV diagnosis among Native American and Alaska Native gay and bisexual men increased 11% from 2018 to 2022, according to the Centers for Disease Control and Prevention.

Despite this increase, Native American and Alaska Native gay and bisexual men are among the groups with the least access to HIV tests outside of health care settings, such as community-based organizations, mobile testing units, and shelters.

As tribes respond to state and federal regulations of two-spirit and LGBTQ+ people, organizations and communities are focused on providing information and resources to protect those in Indian Country, even from the president.

“He will never, ever wipe out our identity, no matter what he does,” Hayes said.

©2025 KFF Health News. Distributed by Tribune Content Agency, LLC.

Dozens killed seeking aid in Gaza as Israel weighs further military action

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By WAFAA SHURAFA, FATMA KHALED and NATALIE MELZER, Associated Press

DEIR AL-BALAH, Gaza Strip (AP) — At least 38 Palestinians were killed overnight and into Wednesday in the Gaza Strip while seeking aid from United Nations convoys and sites run by an Israeli-backed American contractor, according to local health officials. The Israeli military said it had fired warning shots when crowds approached its forces.

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Another 25 people were killed in Israeli airstrikes, according to local hospitals in Gaza. There was no comment from the Israeli military on the strikes.

The latest deaths came as Prime Minister Benjamin Netanyahu was expected to announced further military action — and possibly plans for Israel to fully reoccupy Gaza. Experts say Israel’s ongoing military offensive and blockade are already pushing the territory of some 2 million Palestinians into famine.

Another escalation of the nearly 22-month war could put the lives of countless Palestinians and around 20 living Israeli hostages at risk, and would draw fierce opposition both internationally and within Israel. Netanyahu’s far-right coalition allies have long called for the war to be expanded, and for Israel to eventually take over Gaza, relocate much of its population and rebuild Jewish settlements there.

U.S. President Donald Trump, asked by a reporter Tuesday whether he supported the reoccupation of Gaza, said he wasn’t aware of the “suggestion” but that “it’s going to be pretty much up to Israel.”

More Palestinians killed in scramble for food

Of the 38 Palestinians killed while seeking aid, at least 28 died in the Morag Corridor, an Israeli military zone in southern Gaza where U.N. convoys have been repeatedly overwhelmed by looters and desperate crowds in recent days, and where witnesses say Israeli forces have repeatedly opened fire.

The Israeli military said troops fired warning shots as Palestinians advanced toward them, and that it was not aware of any casualties.

Nasser Hospital, which received the bodies, said another four people were killed in the Teina area, on a route leading to a site in southern Gaza run by the Israeli-backed Gaza Humanitarian Foundation, an American contractor. The Al-Awda Hospital said it received the bodies of six people killed near a GHF site in central Gaza. GHF said there were no violent incidents at or near its sites.

Two of the Israeli airstrikes hit Gaza City, in the north of the territory, killing 13 people there, including six children and five women, according to the Al-Ahli Hospital, which received the bodies.

The Israeli military says it only targets combatants and blames civilian deaths on Hamas because its fighters are entrenched in heavily populated areas. Hamas has been designated as a terrorist organization by the United States, Canada and the European Union.

UN experts say Israeli-backed aid group should be dismantled

Israel facilitated the establishment of four GHF sites in May after blocking the entry of all food, medicine and other goods for 2 1/2 months. Israeli and U.S. officials said a new system was needed to prevent Hamas from siphoning off humanitarian aid.

The United Nations, which has delivered aid to hundreds of distribution points across Gaza throughout the war when conditions allow, has rejected the new system, saying it forces Palestinians to travel long distances and risk their lives for food, and that it allows Israel to control who gets aid, potentially using it to advance plans for further mass displacement.

The U.N. human rights office said last week that some 1,400 Palestinians have been killed seeking aid since May, mostly near GHF sites but also along U.N. convoy routes where trucks have been overwhelmed by crowds. It says nearly all were killed by Israeli fire.

This week, a group of U.N. special rapporteurs and independent human rights experts called for the GHF to be disbanded, saying it is “an utterly disturbing example of how humanitarian relief can be exploited for covert military and geopolitical agendas in serious breach of international law.”

The experts work with the U.N. but do not represent the world body.

The GHF did not immediately respond to a request for comment. The Israeli military says it has only fired warning shots when crowds threatened its forces, and GHF says its armed contractors have only used pepper spray and fired into the air on some occasions to prevent deadly crowding at its sites.

Israel’s blockade and military offensive have made it nearly impossible for anyone to safely deliver aid, and aid groups say recent Israeli measures to facilitate more assistance are far from sufficient.

Hospitals recorded four more malnutrition-related deaths over the last 24 hours, bringing the total to 193 people, including 96 children, since the war began in October 2023, according to the Gaza Health Ministry.

Jordan says aid convoy attacked by Israeli settlers

Jordan said Israeli settlers blocked roads and hurled stones at a convoy of four trucks carrying aid bound for Gaza after they drove across the border into the Israeli-occupied West Bank. Israeli far-right activists have repeatedly sought to halt aid from entering Gaza.

Jordanian government spokesperson Mohammed al-Momani condemned the attack, which he said had shattered the windshields of the trucks, according to the Jordanian state-run Petra News Agency.

The Israeli military said security forces went to the scene to disperse the gathering and accompanied the trucks to their destination.

Hamas-led terrorists killed some 1,200 people, mostly civilians, in the Oct. 7 attack and abducted another 251. Most of the hostages have been released in ceasefires or other deals. Of the 50 still held in Gaza, around 20 are believed to be alive.

Israel’s retaliatory offensive has killed over 61,000 Palestinians, according to Gaza’s Health Ministry, which does not say how many were fighters or civilians but says around half were women and children. It is part of the now largely defunct Hamas-run government and staffed by medical professionals. The U.N. and independent experts consider it the most reliable source for the number of war casualties.

Khaled reported from Cairo and Melzer from Tel Aviv. Israel. Associated Press writers Stefanie Dazio in Berlin and Sally Abou AlJoud in Beirut contributed to this report.

A young surgeon tries to save lives at a crippled Gaza hospital

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By SARAH EL DEEB

At Shifa hospital in the Gaza Strip, nothing is sterilized, so Dr. Jamal Salha and other surgeons wash their instruments in soap. Infections are rampant. The stench of medical waste is overwhelming. And flies are everywhere.

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Without painkillers, patients moan while lying on metal beds lining the corridors. There’s no electricity and no ventilation amid searing heat, leaving anxious visitors to fan bedridden relatives with pieces of cardboard.

Shifa, once the largest hospital in Gaza and the cornerstone of its health care system, is a shell of its former self after 22 months of war. The hospital complex the size of seven soccer fields has been devastated by frequent bombings, two Israeli raids and blockades on food, medicine and equipment. Its exhausted staff works around the clock to save lives.

“It is so bad, no one can imagine,” said Salha, a 27-year-old neurosurgeon who, like countless doctors in Gaza, trained at Shifa after medical school and hopes to end his career there.

But the future is hard to think about when the present is all-consuming. Salha and other doctors are overwhelmed by a wartime caseload that shows no sign of easing. It has gotten more challenging in recent weeks as patients’ bodies wither from rampant malnutrition.

Shifa was initially part of a British military post when it opened in 1946. It developed over the years to boast Gaza’s largest specialized surgery department, with over 21 operating rooms. Now, there are only three, and they barely function.

Because Shifa’s operating rooms are always full, surgeries are also performed in the emergency room, and some of the wounded must be turned away. Bombed-out buildings loom over a courtyard filled with patients and surrounded by mounds of rubble.

Salha fled northern Gaza at the start of the war — and only returned to Shifa at the beginning of this year. While working at another extremely busy hospital in central Gaza, he kept tabs on Shifa’s worsening condition.

“I had seen pictures,” he said. “But when I first got back, I didn’t want to enter.”

A young doctor and a war

After graduating from medical school in 2022, Salha spent a year training at Shifa. That is when he and a friend, Bilal, decided to specialize in neurosurgery.

But everything changed on Oct. 7, 2023, when Hamas attacked Israel and Israel’s retaliatory campaign began.

For the first few weeks of the war, Salha was an intern at Shifa. Because Israel had cut off Gaza’s internet service, one of Salha’s jobs was to bring scans to doctors around the complex. He had to navigate through thousands of displaced people sheltering there and run up and down stairwells when elevators stopped working.

Once Israeli troops moved into northern Gaza, he and has family left. Bilal, who stayed in Gaza City, was killed a few months later, Salha said.

Not long after Salha left, Israeli forces raided Shifa for the first time in November 2023.

Israel said the hospital served as a major Hamas command and control center. But it provided little evidence beyond a single tunnel with two small rooms under the facility.

It made similar arguments when raiding and striking medical facilities across Gaza even as casualties from the war mounted. Israel says it makes every effort to deliver medical supplies and avoid harming civilians.

Under international law, hospitals lose their protected status if they are used for military purposes. Hamas has denied using hospitals for military purposes, though its security personnel can often be seen inside them and they have placed parts of hospitals off limits to the public.

Israeli forces returned to Shifa in March 2024, igniting two weeks of fighting in which the military said it killed some 200 combatants who had regrouped there.

The hospital was left in ruins. The World Health Organization said three hospital buildings were extensively damaged and that its oxygen plant and most equipment were destroyed, including 14 baby incubators.

Ambulances are parked next to the main buildings of Shifa Hospital in Gaza City, Friday, July 4, 2025. (AP Photo/Jehad Alshrafi)

While all this was going on, Salha worked at a hospital in central Gaza, where he performed over 200 surgeries and procedures, including dozens of operations on fractured skulls. Some surgeons spend a lifetime without ever seeing one.

When he returned to Shifa as a neurosurgeon resident, the buildings he used to run between — some had been rehabilitated — felt haunted.

“They destroyed all our memories,” he said.

A shrunken hospital is stretched to its limits

Shifa once had 700 beds. Today there are roughly 200, and nearly as many patients end up on mattresses on the floor, the hospital manager said. Some beds are set up in storage rooms, or in tents. An extra 100 beds, and an additional three surgery rooms, are rented out from a nearby facility.

An injured boy lies on a blanket on the floor as he waits for treatment at Shifa Hospital in Gaza City, July 6, 2025. (AP Photo/Jehad Alshrafi)

The hospital once employed 1,600 doctors and nurses. Now there about half as many, according to Shifa’s administrative manager, Rami Mohana. With Gaza beset by extreme food insecurity, the hospital can no longer feed its staff, and many workers fled to help their families survive. Those who remain are rarely paid.

On a recent morning, in a storage room-turned-patient ward, Salha checked up on Mosab al-Dibs, a 14-year-old boy suffering from a severe head injury and malnutrition.

“Look how bad things have gotten?” Salha said, pulling at al-Dibs’ frail arm.

Al-Dibs’ mother, Shahinez, was despondent. “We’ve known Shifa since we were kids, whoever goes to it will be cured,” she said. “Now anyone who goes to it is lost. There’s no medicine, no serums. It’s a hospital in name only.”

There are shortages of basic supplies, like gauze, so patients’ bandages are changed infrequently. Gel foams that stop bleeding are rationed.

Shifa’s three CT scan machines were destroyed during Israeli raids, Mohana said, so patients are sent to another nearby hospital if they need one. Israel has not approved replacing the CT scanners, he said.

Patients wait for hours — and sometimes days — as surgeons prioritize their caseload or as they arrange scans. Some patients have died while waiting, Salha said.

FILE – A poorly ventilated and unsanitary warehouse built in the yard of Shifa Hospital is crowded with patients, July 6, 2025, in Gaza City. (AP Photo/Jehad Alshrafi, File)

After months without a pneumatic surgical drill to cut through bones, Shifa finally got one. But the blades were missing, and spare parts were not available, Salha said.

″So instead of 10 minutes, it could take over an hour just to cut the skull bones,” he said. “It leaves us exhausted and endangers the life of the patient.”

When asked by The Associated Press about equipment shortages at Shifa, the Israeli military agency in charge of aid coordination, COGAT, did not address the question. It said the military ’’consistently and continuously enables the continued functioning of medical services through aid organizations and the international community.″

Unforgettable moments

From his time at the hospital in central Gaza, Salha can’t shake the memory of the woman in her 20s who arrived with a curable brain hemorrhage. The hospital wouldn’t admit her because there were no beds available in the intensive care unit.

He had wanted to take her in an ambulance to another hospital, but because of the danger of coming under Israeli attack, no technician would go with him to operate her ventilator.

Dr. Jamal Salha tends to a young patient at Shifa Hospital in Gaza City, July 7, 2025. (AP Photo/Jehad Alshrafi)

“I had to tell her family that we will have to leave her to die,” he said.

Other stories have happier endings.

When a girl bleeding from her head arrived at Shifa, Salha’s colleague stopped it with his hand until a gel foam was secured. The girl, who had temporarily lost her vision, greeted Salha after her successful recovery.

“Her vision was better than mine,” the bespectacled Salha said, breaking a smile.

“Sometimes it seems we are living in a stupor. We deal with patients in our sleep and after a while, we wake up and ask: what just happened?”